Recently, multidisciplinary PE response teams (PERT teams) have become popular as a strategy to handle this disorder. If we split patients apart on the basis of severity, then it becomes difficult to recruit a large enough population to study with statistical power.If we lump patients with different severity together, then results become difficult to interpret (perhaps the study intervention is helping some patients within the cohort, but not others). This is a prime example of the lumping-vs-splitting paradox common in researching many critical illnesses: Given that PE is a heterogeneous and emergent condition, it should come as no surprise that our evidence basis is far from complete. To complicate matters further, patients can evolve rapidly in one direction or the other. This is a highly heterogeneous disease, spanning the gamut from patients who are doing pretty well to patients who are profoundly ill.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |